Back in 1994, shortly after she began work on her doctorate at the University of Athens and Greece’s Pasteur Institute, Katerina Akassoglou, PhD, made an important discovery. She and her fellow researchers found that mice that had certain types of immune system-regulating molecules in their brains developed mobility symptoms similar to those experienced bu people with multiple sclerosis.

Scientists at that time didn’t know about how immune cells acted inside the brain, especially in people with MS. Most of the studies prior to Akassoglou’s work focused on the role of the immune system in the body. The brain’s immune system was a whole new frontier, with the potential for more treatment options and targets for MS therapies than previously thought.

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